Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

SOURCE 2021: Gene 78 Analysis of Persistence: Face the Function

Presentation Details

Title: Gene 78 Analysis of Persistence: Face the Function

Presenters: Alexis Forbes

Faculty Supervisor: Dr. Holly Nance 

Abstract: The bacteriophage Persistence was isolated and sequenced for further annotation of its genome. Persistence's genome is a striking 98 genes long and presented several mysteries for analysis throughout the semester. A particular gene of interest, Gene 78, was found to have some inconsistencies regarding its function. When submitted to BLAST sequence alignment, it produced no significant matches. In HHPred, it produced a match with a probability of 99.6 % for a Replisome Organizing protein that is not presented on the Official SEA-PHAGES Function List, as well as a Replicative Helicase with probability 89.1% that is present on the list. However, because there were no domains identified within this gene, I determined that there was insufficient supporting evidence to assign this gene a function, but the data suggest it is involved in DNA replication.